Hepatobiliary Scintigraphy and Glass 90Y Radioembolization with Personalized Dosimetry: Dynamic Changes in Treated and Nontreated Liver

Background: The functional changes that occur over time in the liver following 90Y-radioembolization (RE) using personalized dosimetry (PD) remain to be investigated. Methods: November 2016–October 2019: we retrospectively included hepatocellular carcinoma (HCC) patients treated by 90Y-glass RE PD, who underwent hepatobiliary scintigraphy (HBS) at baseline and 15 days, 1, 2, 3, 6 months after RE. Results: There were 16 with unilobar disease (100%) included, 64 HBS performed. Whole function significantly decreased time. loss was maximal 2 weeks: −32% (p = 0.002) remained below 1 (−15%; p 0.002), (−25%; < 0.001), 3 (−16%; 0.027). No radioembolization-induced observed. Treated strongly reach −64% 0.001) months. Nontreated weeks (−21%; 0.027) before reaching +20% +59% months, respectively. Volumetric exhibited parallel evolutions livers 0.01) but independent nontreated 0.08). Conclusion: PD induces significant regional As early as days RE, both showed a function. recovered greatly increased afterwards.